The OPTIMISE your health study

Recent research has shown that reducing and breaking up sitting time has beneficial effects on blood glucose control and insulin levels in people with type 2 diabetes. This study will test whether an intervention targeting sitting time can help improve glycaemic control in office workers with type 2 diabetes.

The NHMRC-funded OPTIMISE your health study is the first rigorously controlled field-based trial to examine the effects of reducing and breaking up prolonged sitting time on glycaemic control in office workers with T2D.

OPTIMISE draws and builds on two main strands of our research. The first is our world-leading Stand Up Australia program of studies, which have demonstrated substantial (>1.3–16hrs/day) reductions in overall sitting time in general adult working populations using multi-component interventions similar to what we propose here.

It also builds on the findings from our laboratory studies at the Baker Institute, showing that substantial (↓ 39%) reductions in postprandial glucose (PPG; a significant contributor to overall glycaemic control — HbA1c) can be acutely [1-day] achieved by reducing and interrupting prolonged sitting time.

To date, all of the published trials describing the beneficial effects of breaking up sitting time on PPG have been restricted to acute exposure periods (1–5 days). Given that almost all such acute experimental studies have been conducted in laboratory settings, there is a need to experimentally test whether these changes are possible within everyday life settings and over longer time periods. This is crucial for understanding the potential of this approach for clinical and public health translation. OPTIMISE your health is pragmatic trial of an intervention that has the potential for immediate real-world applicability. It is novel in that it specifically addresses new and emerging health threats as outlined in the NHMRC Strategic Direction 2015–16 to 2018–19: address the social, environmental and community dimensions of health, with prolonged sitting due to technological and economic changes being the case in point.

Click here for more information or to join the OPTIMISE study.